Working Group on Modelling, Monitoring, Measurement & Control

Chairman Prof. Dr.-Ing. Clemens Posten University of Karlsruhe Institute for Mechanical Engineering and Mechanics  Kaiserstraße 12,  Geb. 30.70 76131 Karlsruhe Germany Tel: ++49 (0)721 - 608 2410 Fax :++49 (0)721 - 608 2405  Email clemens.posten@mvm.uka.de Website: www.m3c.esbes.org

Vice-Chairman Prof. Dr. Carl-Fredrik Mandenius University of Linköping Sweden Tel: +46 13 288967 Email: mancf@ifm.liu.se

Introduction
In bioprocesses for production of valuable compounds complex dynamic interactions inside the cells and between the cells and the reactor rule the behaviour of the bioprocess. These phenomena have to be measured, observed, understood, and finally controlled in order to achieve best process performance with respect to productivity, reliability, and last but not least process and product safety. The Working Group for Measurement, Monitoring, Modeling and Control (WG-M3C) should stimulate the advancement of these fields within the biochemical engineering science by providing a platform for communication, education and scientific activities. The M3C Working group is an interface between European industry and academia.

Mission
Working group M3C is the meeting platform for people from industry and academics who are interested in sharing knowledge, know-how and scientific ambition in the field of bioprocesses. This can be related to sensors, control including software application, in general knowledge - especially model - based running and developing of fermentations and downstream processes.
Some of WG members are in responsable positions in industrial production and therefore interested in PAT (Process Analytical Technologies) and in adaption of new technologies in these fields, other may be active in teaching and related application of process simulation. The scientific interests reach from macroscopic bioreactor level to molecular appoaches like proteomics targetted to better process understanding, optimization, and finally to application to real processes.

Future activities

• M3C will show strong involvement in the PAT (Process Analytical Technologies) initiative of the FDA.
• M3C will bring technologies on the molecular level (Genomics, Proteomics, Metabolomics) into practical application for process development.
• M3C has started a new membership initiative especially directed to industrial members. Exchange of scientific know-how and practical demands will be increased with mutual benefit.
• In the field of teaching and training (e-book about modelling, plant simulators) running activities will be bundled.